As a result, in full agreement with our interpretation in the initial submission, YidC mutants V500C and T503C in TM5 do not crosslink to the nascent chain.
Indeed, after systemic administration of these [H]GCs, we also showed the presence of radiolabeled by-products in the plasma, which would make accurate data interpretation in the initial 2001 and 2003 studies difficult (13).
A second reviewer (Charles A. Inderjeeth) reviewed all publications meeting the inclusion criteria as well as those deemed to meet some criteria and helped resolve difference in interpretation with the initial reviewer (JG).
The response rates also need interpretation in the context of initial trials of bortezomib, where it was used as a single agent in patients with relapsed MM.
The second interpretation of the initial drop in head-dipping frequency is that head-dipping could represent a fearful, neophobic response, such that, on first exposure to the apparatus, the animal actively attempts to find an escape route (Renner, 1990).
However, it needs to be taken into account that initial studies of genetic associations frequently tend to over-estimate true effect sizes [ 174]; thus, we need to be cautious about interpretation of the initial studies of endophenotypes in relatively small sample sizes.
We defined discrimination as "being unfairly prevented from doing something or being treated unfairly," which was the dominant interpretation provided by participants in the initial qualitative study 19 20 and is consistent with the well established and validated definitions of discrimination 21 23 24 25 and of genetic discrimination specifically.
SR and SB supervised interviewers in the field and contributed to data interpretation and the initial manuscript.
MP conceived the project, participated in the design, data acquisition, analysis and interpretation, drafted the initial manuscript and approved the final manuscript as submitted.
Such an explanation of the data would still show a remarkable relationship between neural responses and the interpretation of the image: ∼36% of the variance in the initial interpretation of images, as reflected in the classification task, would be explained by the response of the single neurons (Fig. 5D).
The sponsor monitored the trial, collected and analysed data, was involved in data interpretation and drafted the initial manuscript from an outline agreed by all authors.
