The authors combined mathematical modeling with TREC measurements and cell division rates in naïve T cells of healthy and HIV-1 infected individuals, in order to obtain a better interpretation of TREC measurements in respect to thymic output.
Interpretation of such studies, in respect to human health risk, might be very difficult because of the temperature increase of the animal.
This highlights the need for further research on the mechanisms involved causing methodology-dependent differences, some of which we discuss, in order to increase the validity of interpretations across studies and in respect to the subject's ecology.
JKCM assisted in the analysis and interpretation of the data especially in respect to the data obtained with the murine mAb Guy13.
In respect to interpretation of data shown in Figure 3G, the experiment simply shows that PhLP1 is ineffective when activated Gαs is provided in the assay, because exogenous Gαs-GTP would compete with endogenous Gαolf-GDP released by PhLP1.
See John R. Sand & Gravel Co. v. United States, 552 U. S. 130, 139 (2008) ("[S]tare decisis in respect to statutory interpretation has 'special force,' for 'Congress remains free to alter what we have done.' " (quoting Patterson v. McLean Credit Union, 491 U. S. 164, 172 173 (1989))).
The interpretation is then limited to men in respect to occupation.
Regarding sensitivity, however, published studies in this area are highly variable in respect to sample size, type of assay, interpretation criteria, study population and TB endemic setting.
While the data from this study are limited in their interpretation with respect to the clinical state of diabetes, this model provides data supporting clinical observations of decreased genital arousal in women with diabetes mellitus.
