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Therefore, we used the results obtained using the Trinity assembly for further biological interpretation and functional analysis.
The metabolomics, biological interpretation, and functional pathways of these DEGs were constructed by KEGG and STRING [ 48].
DAK contributed in the supervision of the complete work, in the interpretation and functional evaluation of the results, co-drafted, co-revised and proofread the manuscript.
Debbie Nickerson (University of Washington, USA) described the advantages of exome over whole-genome sequencing, namely larger allelic effect sizes, easier interpretation and functional follow-up, lower cost and computational savings.
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These problems can impact the accuracy of the interpretation and the functional relationship between a disease state and a genomic sequence.
More than ¾ of these variations likely cause familial hypercholesterolemia as inferred from the predicted effect on structure and 16% are probably benign, with the remainder requiring careful interpretation and further functional analyses to avoid a false positive diagnosis.
We are mindful that observation and interpretation (functional and phylogenetic) need to be kept separate, and thus at this stage reference to gill slits should be taken as a descriptive shorthand.
However, each match is also annotated with sequence similarity and fold information to aid interpretation of structure and functional similarity.
For instance, a young child with giant aneurysms and suspected ischemia will require invasive or CT-angiography, as well as MRI under general anaesthesia, repeated regularly as an individual approach, to obtain the best interpretation of CAA and functional stenosis.
A semi-automatic quantitative interpretation of perfusion and functional data is carried out using standard processing software (Auto QUANT® 5.0.0) [ 42].
Diffusion MR imaging can be incorporated into routine morphological MR imaging to improve radiologist confidence in image interpretation and to provide functional assessments of chest tumors during the same examination.
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