Sentence examples for interpret the functional impact from inspiring English sources

With ClinVar and CADD, VariantDB thus contains two state-of-the-art annotation resources to interpret the functional impact of variants, in addition to several other widely used annotation sources.

Increased understanding of the interplay between the transposable elements and the regulatory machinery of the cell will help us to better interpret the functional impact of SNPs (single nucleotide polymorphisms) and other types of variation within the non-coding portion of our genome [ 13].

The explosion of protein sequences deduced from genetic code has led to both a problem and a potential resource: Efficient data use requires interpreting the functional impact of sequence change without experimentally characterizing each protein variant.

However, in addition to identifying variants accurately, interpreting the functional impacts for large amounts of sequencing data is important to pinpoint potential disease causal genes and mutations.

While we are not claiming every gene in FLAGS is non-pathogenic, we do wish to make it clear that greater biological evidence is required when interpreting the functional impacts of rare variants in frequently mutated genes.

The challenges fall into four main areas: (i) processing large-scale robust genomic data; (ii) interpreting the functional impacts of genomic variation; (iii) integrating data to relate complex interactions with phenotypes; and (iv) translating these discoveries into medical practices.

Thus we can only roughly interpret the functional meaning of this network.

It is therefore often difficult to interpret the functional significance of their subcellular distributions.

A significant reduction in the overall OHIP-14 score can be interpreted as an improvement in the functional impact, psychosocial impact, or both on the oral health in the lives of participants, considering that it denotes a change in the chronic nature of this impact [ 22].

This study had provided the first computational analysis scheme for interpreting the personal genome by simultaneously considering the functional impact of damaging variants and curated disease-gene associations.

In this paper we present the first computational analysis scheme for interpreting personal genome data by simultaneously considering the functional impact of damaging variants and curated disease-gene association data.