Several metrics (normalized assay readouts defined below and summarized in Figure 1) are applied to interpret the functionality and biology of each signaling node and are referenced following the node e.g. "FLT3L→p-Stat5 | Fold", "G-CSF→p-Stat5 | Total" or "p-Stat5 | Basal".
Detailed information on the retrieved public datasets was provided in Additional file 2. In order to interpret the functionality associated with the SNPs, regulatory sequences were annotated in H1 embryonic stem cells, A549 lung cancer, NHLF lung normal, MCF-7 breast cancer, HMEC breast normal, LNCaP prostate cancer, PrEC prostate normal, Caco-2 and HCT-116 colorectal cancer cell lines.
There was also an example of a lack of shared understanding of the goals and purposes of a telecare system, where staff and patients interpreted system functionalities differently, leading to communicative misunderstandings [ 67].
So the team is working on adding functionality that will interpret the importance of calendar items.
Such networks might have interesting topological properties that are biologically meaningful, but are normally difficult to interpret in terms of cellular functionality.
To address delivery barriers, these new PHRs will need to move beyond a record keeping functionality to collect, interpret, and translate medical information for patients.
Our objective is to interpret potential cell type-specific functionality of cancer GWAS SNPs in non-coding regions by incorporating sequence motif information and HTS datasets from the ENCODE project (a workflow overview is presented in Figure 1).
The motivation for the project comes from the rapid expansion of flow cytometry applications that have outpaced the functionality of traditional analysis tools used to interpret flow cytometry data.
"[Y]ou know that only in the future will we have the methodologies to infer these functionalities and to be able to assign and interpret [the genome] at the clinical level," Al-Shahrour says.
We interpret this result as if in this case the interference with the functionality of the OEE is mostly limited to its AE/G− portion (which lies at the 5' of the OEE) and affects only marginally the functionality of the OE+ element inside the OEE module.
