NB analyzed and interpreted database, drafted article DPS conceptualized study and design, involved in drafting and revising article, final approval of published article SE developed design methods and constructed database BC involved in revising article critically for important intellectual content TJW contributed to development of study design and revising article.
A validated database has been shown to be extremely useful, e.g. to test new mathematical algorithms and the INTERPRET database with its 304 cases provides an example of this (9, 21 30).
However, for protection of public health, it is insufficient to develop a biomonitoring database without the ability to interpret that database.
The major challenges in interpreting multiple databases are the lack of reliability, depth and visualization.
A very important, and so far unique, feature in iRefWeb, is that it gives users the ability to readily compare how different databases interpret the same published information, and in case of clear differences, to verify these interpretations directly by examining the original publication.
– What are the competencies an information specialist needs, to access the different databases and interpret their results?
At the same time, experiments have increased in scale, and biologists increasingly use pathways defined in online databases to interpret the results of experiments and generate hypotheses.
During these estimation and learning processes, the PPI interaction mathematical model can derive the most probable PPI network for cancer and normal patients from large amount of microarray data and big databases to interpret the hidden biological mechanisms.
IC helped to program the study database, to transcribe data from PDMSs to the study database, to interpret the results, and to supervise manuscript writing.
Finally, it is challenging for users of biological databases, because in order to correctly interpret the experimental data located in one database, additional information from other databases is frequently needed, requiring the user to learn multiple systems.
