Given the positive experience with the INTERPRET database and the lack of specific funding, a similar solution to INTERPRET could be adopted for the eTDB in the future.
A validated database has been shown to be extremely useful, e.g. to test new mathematical algorithms and the INTERPRET database with its 304 cases provides an example of this (9, 21 30).
The INTERPRET database [ 15] has been used for several years to distinguish different brain tumors in magnetic resonance spectra collected in vivo and the COMET database [ 16] has demonstrated how metabonomics can be applied to the drug safety assessment field.
Expanding the translational capacity of '-omics' platforms for network-based drug discovery depends on developing relevant computational tools to interpret databases and correlations across genomics, transcriptomics, proteomics, metabolomics, microbiome, pharmacogenomics and clinical samples.
NB analyzed and interpreted database, drafted article DPS conceptualized study and design, involved in drafting and revising article, final approval of published article SE developed design methods and constructed database BC involved in revising article critically for important intellectual content TJW contributed to development of study design and revising article.
However, for protection of public health, it is insufficient to develop a biomonitoring database without the ability to interpret that database.
The major challenges in interpreting multiple databases are the lack of reliability, depth and visualization.
A very important, and so far unique, feature in iRefWeb, is that it gives users the ability to readily compare how different databases interpret the same published information, and in case of clear differences, to verify these interpretations directly by examining the original publication.
IC helped to program the study database, to transcribe data from PDMSs to the study database, to interpret the results, and to supervise manuscript writing.
– What are the competencies an information specialist needs, to access the different databases and interpret their results?
At the same time, experiments have increased in scale, and biologists increasingly use pathways defined in online databases to interpret the results of experiments and generate hypotheses.
