If we interpret evolutionary conservation as an indication of function, we believe the conserved sites listed in Table 4 represent those miRNA target sites that are most likely to regulate opsin expression in African cichlids.
More importantly, we interpret the conservation of synteny across poxvirus genomes as evidence against genomic rearrangement events in that region.
Pang et al. [ 56] argue that even slight changes in miRNA sequences can fundamentally alter their function, when they interpret the conservation of miRNAs and snoRNAs.
To interpret this conservation and the cases in which the regularity was violated and recovered, we provide a geometric model that characterizes arm-to-hand and hand-to-arm motion paths as length minimizing curves (geodesics) in a non-Euclidean space.
The high sequence identity of XcOGT with the well-characterised OGTs from human (Haltiwanger et al, 1992), Caenorhabditis elegans (Hanover et al, 2005) and Xenopus laevis allows us to interpret sequence conservation of these metazoan OGTs in the framework provided by the XcOGT structure, revealing a number of striking features.
To minimize interference from splicing signals in interpreting intronic conservation, we excluded 300 bps from both the 5' and 3' ends of each intron [ 42].
The decaying mutual information scores also help us interpret the observation of conservation across populations.
This can be interpreted as the conservation of expression of these gene functions, which are rarely differentially expressed.
Focused on four key social-ecological challenges -- fisheries, forestry, tourism, and energy -- the coupled human-natural systems of Southeast Alaska provide a unique lens for students to interpret broader resource management and conservation issues.
While sequence conservation is usually a clear indicator of important function (for example, structural elements necessary for the correct folding of protein domains), lack of conservation is more difficult to interpret.
