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This fully cellularized vascular construct was tested in a sheep carotid arterial interposition model.
We have developed a severe combined immunodeficiency (SCID) mouse aortic interposition model for initial evaluation and screening of small diameter vascular conduits in vivo.
Using a rat aortic interposition model, early in vivo responses were evaluated at 2 weeks via Doppler ultrasound and CT angiography with immunohistochemistry confirming a limited early inflammatory response (n = 8).
We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation.
Decellularized veins have been developed using also other detergents, such as SDS: decellularized canine external jugular veins have been transplanted in a carotid interposition model in dogs [ 105].
Canine matrices were seeded with bone marrow derived cells, differentiated toward smooth muscle and endothelial cells, and implanted in cell donor dogs in a carotid artery interposition model [ 103].
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Although the aortic interposition bypass model has been widely used to evaluate biomaterials for bypass grafting, there is no comprehensive description of the procedure or of the distribution of intimal hyperplasia that results.
In the present study, we implanted BM-MNC free (unseeded) BM-MNC freele vascunseededfts in a mouse IVC interposition graft model.
The objectives of this study were to (1) review and summarize approaches of aortic interposition grafting in animal models, (2) determine the pertinent anatomy for this procedure, (3) validate this model in the rat and guinea pig, and (4) compare the distribution of intimal hyperplasia that develops in each species.
Moreover, gel release controlled vascular injury in denuding and interposition vascular graft animal models of disease even when uncontrolled bleeding was evident with standard matrix-type release.
The purpose of this study was to clarify the impacts of long-term (24 weeks) administration of aspirin and cilostazol on neotissue hyperplasia causing stenosis after the implantation of bioresorbable vascular grafts as inferior vena cava (IVC) interposition conduits in a mouse model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com