While these events occur in the context of chromatin, our understanding of how TF-nucleosome interplay affects gene expression is highly limited.
Bartholl is more concerned with the relationship between the physical and the digital and how that interplay affects our interaction with them.
13b Although the functional link between NMNAT-1 and PARP-1 has been established, how this interplay affects biological processes requires further study.
Future studies could investigate how multiple partners work together to determine the behavior of calcium channels in specific locations and at specific times, and how this interplay affects how well synapses work in the brain.
This is one reason why we did not focus our paper on these single genes, but instead focused the work on our clear genetic and genomic (cohort average) evidence for antagonism between these two Remodeler families and how this interplay affects promoter/gene architecture at cohorts of genes.
Theoretically, if animals are selected under non-limiting conditions, responses to selection can be achieved without modifying the interplay between life functions, whereas under limiting conditions, this interplay is affected [ 22, 23].
This interplay is affected by the nature of the policy issue (for example, whether the issue is politically and socially sensitive and/or controversial), the contents of a specific policy (i.e. policy options proposed), and the types and characteristics of evidence available around a specific policy [ 4, 18].
Understanding their interplay in affecting the pharmacokinetics of drugs is of prime interest.
As it is widely believed that life requires an aqueous environment, and it is a cornerstone of many ideas regarding the origins of Earth's early organics that the early atmosphere was reducing, it is worth discussing the origin of the Earth's oceans, atmosphere, and crust, as these have a complex interplay which affects their ability to produce organic compounds.
p66Shc-AKT interplay also affects NO production: p66Shc silencing leads to activation of Ras and AKT kinase, with a corresponding increase in phosphorylation of eNOS at Ser-1177.
