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Ideally, these scenarios would, in turn, be determined by using geographically explicit, economic, bottom-up type models, whose methodologies could be validated by this or another international validation entity.
The QLQ-OES18 has recently completed international validation testing (Blazeby et al, 2003) and the QLQ-STO22 is currently being validated in EORTC protocol 15012.
It will be necessary to further validate these findings with additional independent cohorts of samples to meet accepted international validation guidelines [ 55].
Results generated with selected reference chemicals compared very favourably with data obtained from a previous international validation study concerning the prediction of acute systemic toxicity in rodents.
A collective sum score was created to then divide into three equal groups of low, medium and high family affluence, as replicated in an international validation study of the FASIII (Torsheim et al. 2015).
On the basis of the literature search and ongoing international validation efforts by the OECD for methods to detect endocrine disruptive effects, 15 biological test methods (five in vivo and ten in vitro) were selected including eight OECD methods and three out of five in vitro methods mentioned in the Global Water Research Coalition GWRCC) report.
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External validation of the Intego database has been examined by means of national and international comparisons.
Many commercially available assays have been already approved by FDA or have been clinically validated in accordance with international approved validation guidelines.
Validation parameters LOD, LOQ, linearity, recovery, accuracy and imprecision of the assay were studied according to international method validation guidelines in forensic toxicology (SOFT/AAFS, SWGTOX).
Experts in an ad hoc international antibody validation working group published a commentary earlier this month in Nature Methods advocating for application-specific antibody testing.
The results of international field validation has been published in 2008 [ 9].
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