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The MoodSwings 2.0 clinical trial, funded by the National Institute of Mental Health, is an international, randomized trial of three stepped levels of adjunctive treatment (Lauder et al. 2017) (see Fig. 1).
There is an ongoing, multicenter, international, randomized trial testing the role of eculizumab plus conventional treatment (or conventional treatment alone) that may clarify its utility (NCT00670774) 110.
Previous studies [ 11] suggested that the clinical outcome was similar between the single stent and the double stent groups in an international randomized trial for bifurcation lesions.
For instance, evaluation of the impact of an ultra-protective lung ventilation strategy with ECMO for ARDS by a large international randomized trial is now needed.
As a consequence, an international randomized trial study comparing RT + surgery versus surgery alone with quality control of excision mesorectum [ 10] was conducted in 1805 patients.
Such studies include ABLE (The Age of Blood Evaluation Trial) (ISRCTN44878718), an ongoing international randomized trial comparing younger RBCs (stored fewer than 7 days) with standard-issue RBCs.
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Currently, two international randomized trials are investigating sequence and the combination of radiotherapy and chemotherapy in WHO grade III tumors stratified according to 1p/19q status [8], [9].
A large meta-analysis that included more than 1100 patients from nine international randomized trials, demonstrated a significantly higher incidence of extensive cGVHD when using granulocyte colony-stimulating factor-mobilized peripheral blood stem cells versus bone marrow.
Several international randomized trials are being launched under the auspices of the European Group for Blood and Marrow Transplantation stem cell subcommittee targeting acute GvHD treatment and prevention, using standardized expansion protocols and defined culture media based on phase I/II experience [ 57].
This was a multicenter, international, randomized controlled trial (Clinical Trials identifier NCT00354211; ClinicalTrials.gov).gov
Exclusion criteria are: Pathological fractures, i.e. due to underlying malignant disorder Rheumatoid osteoarthritis No written informed consent Inability to understand trial features due to mental handicap or language problems Pregnancy The EF3X-trial is an international randomized multicenter trial, with participation of 4 hospitals (3 university hospitals and 1 regional hospital).
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CEO of Professional Science Editing for Scientists @ prosciediting.com