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The Type II GnRH receptors possess a typical cytoplasmic tail, desensitizing and internalizing within minutes of ligand binding [ 69- 71].
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When fibroblasts were incubated with [125I]oPL at 4 C and then warmed to 37 C, the radiolabeled hormone was internalized within 2-4 Most Mofthef the internalized hormone, however, was recycled rapidly to the cell surface by 6-10 min and released intact by retroendocytosis into the incubation medium.
PTD are short peptide sequences that enable proteins to translocate across the cell membrane and be internalized within the cytosol, through atypical secretory and internalization pathways.
The cell internalization studies showed that the developed GNC formulation gets rapidly internalized within cells, and these results support the successful delivery of siRNA within tumor cells.
pHrodo Red SE label enables fluorescent measurement of internalization based on the increase in fluorescence as the mitochondria are internalized within the cells (Miksa et al., 2009; Neaga et al., 2013).
Confocal microscopy reveals LTP nanospheres are internalized within human fibroblasts.
Compound 17 was rapidly internalized within 30 min and sustained for 24 h.
Cellular uptake study was carried out, indicating that the micelles could be fast internalized within several hours.
The only place where conventional, integer-based arithmetic can be found in the GF1 is the program register, P, where it was internalized within the relevant counter chips.
For therapeutic purposes, different types of drugs, growth factors, and genes may be either internalized within the nanofibers or surface-conjugated.
In addition, caveolin-1 and GM1, lipid raft landmarkers, were internalized within cells after exposure to Rh2, indicating that Rh2 might disrupt lipid rafts.
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