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DOI: http://dx.doi.org/10.7554/eLife.03648.002 Clathrin-mediated endocytosis is a conserved and ubiquitous process for internalizing material from the cell surface.
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These results demonstrated that MR on mononuclear phagocytic cells plays a significant role in internalizing E/S material released by the invasive stages of the parasite, which in turn modulates the production of proinflammatory cytokines.
CD19 and CD20 positive APC were excluded from the analysis as they had likely formed conjugates with B cells but had not necessarily internalized cellular material.
Endocytosis is an active process whereby cells internalize extracellular material through cytoplasmic membranes.
70, 71 In general, only certain types of cells can internalize particulate material with size above 200 nm.
Phagocytosis is the process by which macrophage, neutrophils and dendritic cells internalize particulate material over 0.5 μm in diameter.
Finally, DCs cocultured with netting neutrophils internalize NET material and, when transferred to rodent models, induce a vasculitis-like syndrome [ 51].
Finally, in OVA-allergic mice, we found eosinophils containing AuNP, emphasizing the emerging notion that this cell type may internalize foreign material.
This DC subtype efficiently internalizes antigenic material from necrotic cells, produces high levels of IL-12 and cross-presents exogenous antigens to CD8+ T cells, thus representing the human equivalent of murine CD8 α+ DC.
Complementary to the secretory pathway, there is an endocytic pathway that internalizes extracellular materials and retrieves membrane and proteins from the PM.
Also, keratinocytes, which are the most represented cells in the epidermis (90%), can internalize penetrated materials.
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