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Cancer cells internalized with the GNP drug complex had a 32 ± 9% decrease in cell survival and statistically significant enhancement in DNA (deoxyribonucleic acid) damage as compared to control cells (irradiated with no GNPs) after receiving a radiation dose of 2 Gy with 6 MV photons.
That a subpopulation of the dual-coloured EVs was not stained (white arrows, inset) indicated that EV particles were internalized with the outer membrane.
By contrast, in those marine crustaceans with holoblastic cleavage and hollow blastulae, the mesoderm originates from a small subset of vegetal blastomeres internalized with the endoderm during gastrulation, usually in the form of two lateral bands [ 10, 69].
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In control cells, the three SNAREs were rapidly internalized, with 40%60%% of the prebound antibody already inside the cells after 5 min.
It appears, from our data, that although LRP6 is internalized with similar kinetics in the presence or absence of Dab2, once internalized the endocytic fate of the receptor is distinct.
As expected, AF555-EGF was internalized with strong co-localization with the EGFR-GFP (Fig. 2a).
These externalities can be internalized with present methodologies in the literature.
Because TRAIL can be internalized via receptor-mediated endocytosis [ 24], we hypothesized that iron superoxide dismutase (FeSOD) could be internalized with sTRAIL to reduce the level of intracellular O2-.
The [125I]SGMIB-MNT conjugate was rapidly internalized, with more than 60% of internalized [125I]SGMIB-MNT radioactivity accumulating in the cell nuclei after a 1-h incubation.
Functional studies showed that the A21 scFv could be internalized with high efficiency after binding to the ErbB2-overexpressing cells, suggesting this regent may prove especially useful for ErbB2-targeted immunotherapy.
The sensor was internalized with human cervical cancer HeLa cell lines.
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