Ligand binding to GnRHR may be the stimulus for the nuclear internalization of the receptor since GnRH has been shown to be rapidly internalized to the nuclear membrane prior to entry into the nucleus [ 18].
Caspase activation was blocked because of the inability of CerS2 null mice to internalize the TNFR1; whereas Fc-TNF α was internalized to a perinuclear region in hepatocytes from wild-type mice, no internalization was detected in CerS2 null mice.
Directing the cast, Kieslowski avoids even a hint of melodrama, and most of the performances are restrained and internalized to the brink of introspection.
In the Pines, Mr. Bianchi said, "We as gay men were finally able to let go of the judgments we'd internalized, to take each other's hands and help each other explore".
In contrast, (PEG + PVA -NH2 and PVA -NH2andPs were internalized to a higher extent and caused interleukin-1beta secretion.
When cells were exposed to MNPs, most nanoparticles were first adhered to the surface, internalized to the cells by endocytosis, and accumulated in digestive vacuoles [32].
The dimeric compound [68Ga]7 significantly showed higher cellular uptake (40.04 ± 6.09% (dimer), 23.24 ± 2.17% (monomer); P = 0.01), while both substances were internalized to approximately 25%.
This peptide is internalized to the same extent as the cell-penetrating peptide (CPP) TP10 and dose-dependently decreases proliferation in MCF-7 and MDA MB 231 cells.
Parsonian norms are internalized to the point that their existence can be elicited only when the norm is violated, and conformity to such norms is clearly unconditional.
The Sr-MBN is internalized to most MSCs via an ATP dependent macropinocytosis within hours, increasing the intracellular levels of Sr, Ca and Si ions.
Live-cell imaging showed that both types of complexes were internalized to quantitatively similar particle distributions within the first 2 h of incubation with cells.
