Whether the pain stems from the feelings of rejection of an absentee parent, or from the socio-economic barriers to living the American dream, a lot of black men internalize a range of negative feelings that impact every aspect of their lives.
Although S. aureus is primarily an extracellular pathogen, there is strong evidence that it can be internalized by a wide range of human host cells.
Members of the LDLR (low-density lipoprotein receptor) family are involved in binding and internalizing a wide range of structurally unrelated proteins [ 1, 2].
Macrophages constitutively internalize a wide range of complex glycoproteins, proteoglycans, and glycosaminoglycans that are degraded by lysosomal glycosidases to generate free sugars or oligosaccharides.
It is a constitutively active cell surface receptor capable of binding and internalizing a large range of structurally and functionally different types of protein ligand, and has been shown to be essential for life [ 1].
In particular, DC-SIGN is actively studied due to its ability to bind and internalize a broad range of bacterial and viral pathogens, including HIV-1 and Mycobacterium tuberculosis (reviewed in [ 65]), while MManR is also implicated in binding and phagocytosis of a wide range of microorganisms [ 66].
Clinical range behavioral problems in at least one of the CBCL scales examined were observed in 42% of the children assessed, with levels of clinical range internalizing (28%) and externalizing (22%) scores comparable to those for youth in care centers in other countries [ 4- 6].
A range of different cell types readily internalized our nanodisk lasers (Fig. 3a, Supplementary Figs. 5 and 6, Supplementary Movie 1), presumably via natural endocytosis or phagocytosis26.
Moreover, within the range of concentrations investigated, these systems were internalized in the monolayer in a concentration-dependent manner.
It was recently found that CTX not only binds a wide range of tumor cell types but is also internalized by proliferating human vascular endothelial cells [ 23].
