Several studies by us and others utilizing I-ANP-binding analyses have demonstrated that bound ANP/NPRA complexes are internalized, processed intracellularly and the degraded products released into culture medium [ 17, 22– 27].
We compared how free and opsonized HIV-1 were internalized, processed, and presented on MHCI or MHCII molecules by IDCs and MDCs (Fig. 1 A D: normalized data; Supporting Information Fig. 1A D: representative experiments).
DCs express receptors that recognize and bind a large array of epitopes or antigens common to many bacterial or viral pathogens; once an antigen is recognized, it is internalized, processed, and presented at the cell surface in association with molecules of the major histocompatibility complex (MHC).
DCs can internalize, process and present MP in the context of the MHC II to CD4+ T-cells [13].
Dendritic cells (DC) are the most potent antigen presenting cells, because they can internalize, process and present antigens in order to activate T-cells.
The requirement for Environmental Impact Statements prompted numerous complaints at the time, but today, we've internalized the process.
From the study of philosophy at Harvard through his arbitrage experience at Goldman, Rubin internalized "a process of weighing odds in a world without absolutes or provable certainties".
As a result of macrophage activation, conjugated Au NPs were internalized and processed.
This large spread of peak wavelengths may be attributed to cells each being in different stages of the cell cycle, with some cells just starting to internalize NPs and other cells already having internalized and processed NPs from early endosomes to late lysosomes for a longer time.
Once the source antigen has been internalized and processed, one would a priori expect that any peptide derived from this source antigen would be offered to MHC class II and could be presented.
