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In addition to the direct interactions with the receptors, the accumulation of chemicals in the internalized part of the membrane, and the binding of chemicals to the internalized macromolecules must be included.
According to our model of moral intelligence, which is proposed to provide an integrative framework for understanding moral behavior [ 27], moral values are, if internalized, part of the individual's "moral compass" that helps to guide behavior.
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They are, instead, a reflection of her internalized journey, part of the process of becoming whole.
Endocytosis of BODIPY-SM occurs via caveolae with part of internalized BODIPY-fluorescence ending up in the Golgi and the ER.
However, it was reported that in some cases a small part of the internalized cells dies by apoptosis pathway10.
Using ELISA, we found that a large part of the internalized transferrin (63.2%) remained in the dynasore-treated cells even after 120 min, by which point almost all of the internalized transferrin was recycled; only 12.8% remained in the control cells (Fig. 2A).
Whether the internalized transceptors, for instance as part of a separate, protected pool, play a role in keeping PKA activity high is unclear.
Systematic investigation of the extent and correlates of internalized stigma is an essential part of planning for recovery programs for schizophrenia.
Although association with the endogenous protein target has been observed, part of the internalized TAT-fusion inhibitors may be sequestered into intracellular compartments and become inaccessible [35].
Extracellular α-synuclein, once secreted, is subject to endocytosis by adjacent cells and at least a part of the internalized α-synuclein is re-secreted, which could represent a key step in the cascade that allows cell-to-cell propagation of α-synuclein aggregates [ 49– 51].
The majority of GF/GFR complexes on the cell surface get internalized and degraded in lysosomes, perhaps as part of the receptor-turnover pathway (for review see [46], [47]).
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