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The released agents were internalized into the cells via lipid raft/caveolae-mediated endocytosis using total internal reflection fluorescence microscopy (TIRFM) and endocytic inhibitors.
These results suggest that GMBP1 was internalized into the multi-drug resistant gastric cells and that this internalization was receptor mediated.
Transmission electron microscopy reveals that the nanoprobes are internalized into the cytoplasm of MSCs.
The nanocapsules were demonstrated to be efficiently internalized into the cells and to release the protein in the reducing cytosol.
DOX is released from the conjugate and internalized into the cells in 4 h, causing cellular toxicity.
The nanoparticles were internalized into the cells and the apoptotic topography can be directly visualized simultaneously with MFM technology.
"Imagine if you could visually follow a virus as it approaches and is internalized into the cell," says Kevin Welsher, a postdoctoral researcher in the Yang lab.
These drug encapsulated nanomicelles were found to be successfully internalized into the MCF-7 cells to demonstrate high-quality fluorescent images.
Moreover, CCN could be internalized into the enterocytes by clathrin-mediated endocytosis pathway, and thereafter transported into systemic circulation via both portal vein and lymphatic pathway.
There has been no report in the literature that involves the fate of micelles after successfully internalized into the cancer cells.
The protein actively internalized into the cells and showed superior protection against oxidative stress-induced cell death over native enzymes fused with TAT.
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CEO of Professional Science Editing for Scientists @ prosciediting.com