Recycling endosomes are key platforms for endocytic recycling that return internalized molecules back to the plasma membrane.
Endocytic recycling is an intracellular process that returns internalized molecules back to the plasma membrane,, and it plays crucial roles not only in the reuse of receptor molecules but in remodeling of the protein and lipid composition of the plasma membrane.
This involves recapturing the proteins that make up the synaptic vesicle and internalizing them back into the presynaptic terminal.
To this end, TJ proteins are continuously internalized and recycled back to the plasma membrane via endocytosis.
A recent study demonstrated a possible new role of Rab7 in the recycling of membrane type 1-matrix metalloproteinase (MT1-MMP), as the delivery of internalized MT1-MMP back to the plasma membrane is dependent on Rab7.
Confirming that TfR is internalized and recycled back to the PM, knock-down of Rab11, required for recycling endosome trafficking (Maxfield and McGraw, 2004), caused TfR vesicles to fill the cytoplasm while no TfR was detected at the PM.
The work proceeded slowly, and the directors internalized their anxiety, suffering back aches and chest pains.
Following ligand binding, most receptors are recruited to clathrin-coated pits where they are endocytosed then internalized and either recycled back to the cell surface or degraded within intracellular compartments.
This gives no detectable ubiquitination, and instead of being degraded, internalized EGFRvIII is recycled back to the plasma membrane (Grandal et al. 2007).
Their purpose is to "internalize --put back on the offendinternalize --putinternalize --putt they are currently imposing on the rest of us....the key to the plan is that it does not tax the back's assets, on whathehey offendingaxes their liabilities, or what they owe.
