Ligand binding to GnRHR may be the stimulus for the nuclear internalization of the receptor since GnRH has been shown to be rapidly internalized to the nuclear membrane prior to entry into the nucleus [ 18].
Directing the cast, Kieslowski avoids even a hint of melodrama, and most of the performances are restrained and internalized to the brink of introspection.
When cells were exposed to MNPs, most nanoparticles were first adhered to the surface, internalized to the cells by endocytosis, and accumulated in digestive vacuoles [32].
Parsonian norms are internalized to the point that their existence can be elicited only when the norm is violated, and conformity to such norms is clearly unconditional.
One cannot deny that there exist norms that our society has internalized to the point that almost no variance exists in norm-induced behaviors.
This peptide is internalized to the same extent as the cell-penetrating peptide (CPP) TP10 and dose-dependently decreases proliferation in MCF-7 and MDA MB 231 cells.
Taken together, these results confirm that in metastatic K1735-M1 and B16-F1 melanomaelanoma cells, AMF/PGI is internalized to the smooth endoplasmic reticulum via a raft-dependent pathway.
We hypothesized that the decreased potency of LF-HMA could be due to the lower stability of protein once it is internalized to the cell cytosol, as might occur if the N-end rule were operative for LF.
It is known that TLR2 can be internalized to the Golgi apparatus following the binding to LTA and it was also suggested that receptor internalization is required for TLR2-dependent production of type 1 IFN [18], [33].
Aggrecan fragments are internalized to the cells and degraded further in lysosomes by their proteolytic machinery, the cathepsins.
