Sentence examples for internalization without from inspiring English sources

Among the various inhibitors we have tested, we found that the lipid raft inhibitor (mβCD), Lyn tyrosine kinase inhibitor (PP2), Akt inhibitor, and NF-κB inhibitor effectively blocked adhesion and internalization of P. aeruginosa, whereas the ceramide inhibitor (blocking sphingolipid pathway) only reduced internalization without affecting adhesion (Figure 2G, Table 1 and Figure S2B).

Furthermore, specific mutations can radically alter superactivation or internalization without affecting the efficacy of acute Gi signaling.

This schedule is effective likely due to rapid CD22 internalization without return of CD22 to the cell surface for nearly 2 weeks due to persisting HB22.7 levels.

Indeed, our hypothesis, that increased respiratory benefit drove the initial association and subsequent internalization without any intermediate stages of exchanging metabolic waste products, is the most direct route.

Notably, the non-electroporated control occasionally includes cells that exhibit high fluorescence, most likely corresponding to damaged cells whose membranes are compromised and can allow internalization even without electroporation.

PECAM-1 antibodies bind to ECs without internalization, but ECs internalize by endocytosis nanocarriers carrying multiple copies of anti-PECAM (anti-PECAM/NCs).

Because both 95 M and 80 M were internalized without activating neutrophils, our data demonstrate that internalization of a polysaccharide biomaterial does not automatically trigger degranulation.

Regulators of G protein signaling (RGS) proteins could also play a role in the desensitization of D2 receptors without internalization.

On the other hand, fibroblast proliferation in media containing ICSNPs was the highest, probably because immobilized insulin molecules sufficiently and continuously stimulate receptors expressed on the plasma membrane surface as well as downstream signal transduction proteins without internalization of ligand-receptor complexes [18].

We speculated that upon recognition of apoA-I by SR-BI, the cell membrane would undergo membrane reorganization, resulting in the formation of a non-aqueous "channel" and subsequent cross-membrane transfer of CD-PEI/pDNA cargo from rHDL to cytosolic compartments without internalization of the intact rHDL/CD-PEI/pDNA complexes.

Evidence from previous in vitro studies suggest that GPCR uncoupling can occur without internalization.