Sentence examples for internalization results from inspiring English sources

Subsequently, TNFR1 internalization results in the recruitment of FADD and caspase-8 causing activation of the apoptotic signal through TNFR1-bound complex II.

Consistent with the internalization results (Fig.  4a, b), ES showed weaker interaction with nucleolin than ZBP-ES, whereas M2ES showed increased interaction with nucleolin compared with MZBP-ES (Fig.  4c).

This new aspect of the EGFR endocytosis system is interesting but the supporting evidence is not sufficiently convincing. 1) The equilibrium between constitutive recycling and internalization results in a significantly larger pool of EGFR at the cell surface than in endosomes, at least when distribution of an endogenous EGFR is analyzed.

The former clearly shows that autocatalysis is suppressed by recycling and the latter that EGFR- mCitrine is expressed at about equal levels to endogenous EGFR. 1) The equilibrium between constitutive recycling and internalization results in a significantly larger pool of EGFR at the cell surface than in endosomes, at least when distribution of an endogenous EGFR is analyzed.

These results correlated well with the in vitro Caco-2 internalization results (Fig. 2) as well as previous antibody protection results that showed mice fed with toxins and injected with neutralizing antibodies were only protected if antibodies were given by 6 7 h post oral intoxication (Cheng et al., 2009).

Here, we show that intercellular Celsr1 complexes that connect dividing cells with their neighbors remain intact during mitotic internalization, resulting in an uptake of Celsr1 protein from interphase neighbors.

In contrast, factors that increase total VEGF clearance, e.g. VEGFR-mediated internalization, result in decreased proteolytic conversion.

For example, thiol modification of surface thioredoxin results in its lipid raft-mediated internalization resulting in changes in the intracellular redox state [30].

In this study, we have shown lovastatin does indeed inhibit ligand-induced VEGFR-2 activation through inhibition of receptor internalization resulting in diminished AKT activation in HUVEC and MM cells.

TNFR1 internalization resulted in abrogation of RIP1 and TRAF2 degradation in CerS2 null mice.

Once EGFR is activated it undergoes internalization, resulting in a marked decrease in nonactivated membrane-bound EGFR [ 24].