toxin concentration is much lower than the receptor concentration, for toxins that are internalized, the internalization rate is much slower than establishment of the receptor-toxin binding equilibrium.
These results suggest that the patient antibodies increase net internalization rate of surface AMPARs and that internalized AMPARs are degraded in lysosomes.
Allied Waste's internalization rate is 75%, tops among the larger players.
These include antigen binding affinity; internalization rate, intracellular processing and intrinsic toxin domain potency.
Interestingly, 68Ga/177Lu-12 withethe ffk spacer showed a higher internalization rate than ligand 11 with the FFK spacer.
As a consequence, both the determination of affinity and the internalization rate are crucial for the characterization of PSMA inhibitors.
The targeted dual-drug-loaded micelles showed synergistic cytotoxicity and enhanced internalization rate in mouse melanoma (B16F1) cells.
Coating of the particle surface with polysorbate 80 drops the internalization rate close to zero and the charge dependence disappears.
The comparison of 124I-J591 and 89Zr-J591 yielded similar model-derived values of the total antigen concentration and internalization rate.
For the 180-μg-dose data, the average maximum internalization rate is 1.2 × 1013 molecules per gram of tissue per hour.
Thus, we considered 111In-Fab to be an interesting candidate for the subsequent in vivo studies, despite an expected low internalization rate.
