Sentence examples for internalization of target from inspiring English sources

Inhibition of the surface ubiquitination by down-regulating ubiquitin conjugating enzyme E2 impaired the internalization of target molecules.

However in mammals, it is difficult to analyze the relationship between surface ubiquitination and internalization of target surface molecules as there are no suitable experimental models in mammals.

We previously showed that transient or stable over-expression of c-MIR induces marked internalization of target surface molecules, and its effect is cancelled by inhibition of target molecule ubiquitination.

Considering that PI 4-kinase type II and PI 3-kinase type I are required for Listeria internalization of target cells [40], it is possible that these, and/or other lipid kinases, play a role in the spatial and temporal recruitment of septins during bacterial entry.

Cross-linking of target molecules by a multivalent carrier may induce ill-understood or adverse signaling in the endothelial cells, shedding and/or internalization of target determinants, changes in their functionality, or other disturbances of the endothelium.

However, literature data indicate that the DEC-205 type I C-type lectin receptor is not able to signal and activate transcription factors, while it is efficient in favoring the internalization of target antigens (Mahnke et al, 2000; Cohn et al, 2013).

Dox-induced c-MIR expression initiated rapid internalization of surface target molecules, and blockage of the internalization induced the accumulation of the surface target molecules that were newly ubiquitinated by c-MIR.

In certain situations (e.g., K off ≪ K int), increasing affinity by decreasing K off may yield no benefit because of the fast internalization of the target (Grimm, 2009).

Inhibition of surface ubiquitination by down-regulating E2 impaired internalization of the target surface molecule.

Internalization of these targeted carriers increased with the increase in G5 concentration and incubation time following Michaelis Menten kinetics characteristic of receptor-mediated endocytosis.

Pre-clinical studies have shown a slow rate of internalization of GPC3 targeted with antibody [17, 18].