Sentence examples for internalization of glucose from inspiring English sources
The glucose-dependent expression of DEFB1 and CAMP has a biological relevance because they show constitutive skin expression, probably explained by the constant supply of glucose through blood in a nonstarved state and/or normal internalization of glucose in a nondiabetic host.
For example, Figure 5 shows internalization of Hxt2, a glucose transporter, in response to rapamycin treatment.
First, Rod1 exerts a function at the plasma membrane, as it is essential for the endocytosis of the glycerol/proton symporter Stl1, and required for the efficient internalization of Jen1 upon glucose treatment.
The intracellular glucose concentration after 30 minutes of internalization with glucose was determined to be 0.20 mM using the sensor G-PS.
Cellular internalization and glucose response of the polymer within HeLa cells were investigated.
We show that the ubiquitin ligase Rsp5 and the glucose-regulated arrestin-related trafficking adaptors (ART) protein Rod1, involved in the glucose-induced internalization of Jen1, are also required for the post-endocytic sorting of Jen1 to the yeast lysosome.
Therefore, the continuous presence of glucose is not only required to trigger Jen1 internalization, but also to maintain Jen1 in the endocytic pathway and prevent its recycling.
Rgt2 is also required for glucose-induced maltose permease turnover: rgt2 mutants exhibit reduced internalization and an RGT2 constitutive allele induces turnover even in the absence of glucose (Jiang et al. 1997; Gadura et al. 2006).
To test this prediction, we treated lactate-grown cells expressing Jen1-GFP with a short pulse of glucose (10 min), which was sufficient to drive Jen1-GFP internalization, and then followed Jen1-GFP trafficking upon glucose removal.
In the case of glucose transporters, downregulation can be mediated by ubiquitination of the cytoplasmic tail and internalization and degradation of the transporter in the parasite lysosome.
3. Dual effect of glucose.
