Sentence examples for internalization function from inspiring English sources

More broadly, accession can be seen as the critical legal principle that generates the internalization function of property, insofar as gains and losses attributable to the management of resources are automatically assigned to the most prominently connected property by accession.

Thus, GRKs and beta-arrestins, which uncouple GPCRs and target them for internalization, function as essential elements in the GPCR-mediated MAP kinase signaling cascade.

On a separate front, antibodies specific to tumor surface markers, based on its internalization function, could be used for molecular imaging with different radioisotope labels and aid in diagnostic of tumor type and choice of treatment plans [35].

IF imaging evidence from other groups [ 12, 45] directly demonstrated that phosphorylation of VE-cadherins trigger internalization of VE-cadherin, decreasing endothelial barrier function [ 10].

This is one possible model based on our results presented above; other possibilities no doubt exist, and the binding of AtEHD2 to AP-2 and/or LeEix2 will be examined further in order to elucidate the activity of different protein complexes in LeEix2 internalization and function.

In neurons, expression of Arc leads to increased AMPA-type glutamate receptor internalization, a function that depends on its association with both Endophilin and Dynamin.

By contrast, for the transferrin receptor and other receptors involved in receptor-mediated endocytosis, the internalization presumably functions to carry some specific ligand or metabolite into the cell.

To assess these three receptor internalization-related functions and validate the results, we employed four classical ligands of melatonin receptors: the natural agonist melatonin; the super-agonist 2-iodo-melatonin and the two antagonists luzindole and 4-phenyl-2-propionamidotetralin.

Finally, removal of cell surface receptors such as the TCR via endocytic transport contributes in various ways to IS function: internalization and subsequent recruitment to IS ensures high local concentrations at the IS while TCR internalization can also lead to lysosomal degradation and thus termination of signaling [20].

We further evaluated ICAM-1 as a MM targeting moiety by characterizing its (1) tumor specificity, (2) expression level, (3) cellular internalization, (4) therapeutic function, and (5) potential clinical impact.

When methamphetamine binds to TAAR1, it triggers transporter phosphorylation via protein kinase A (PKA) and protein kinase C (PKC) signaling, ultimately resulting in the internalization or reverse function of monoamine transporters.