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This effect is likely attributable to the differences in modes of internalization for the two forms of Cu.
Fig. 6 Simulated rate of surface binding and internalization for 180-μg Ab doses of 124I- and 89Zr-J591.
Therefore, by conjugating the ligands of these receptors to nanoparticles it is possible to achieve cell-specific internalization for potential drug delivery or imaging.
Our coupling strategy allows us to capitalize on the pH gradient observed along the endosome/lysosome pathway for particle internalization for targeted delivery of Cu [1].
This consideration underscores the importance of the binding-induced TCR internalization for development of the properly delineated TC-APC interface.
Cultured bovine chromaffin cells were treated in vitro by clostridial neurotoxins, using a low ionic strength medium to enable the BoNT internalization for 24 hours [14], [15].
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In the case of BORON TRANSPORTER 1 (BOR1), however, down-regulation requires the combined action of ubiquitin and tyrosine-based sorting signals for internalization and for endosomal sorting [ 22].
However, stem cells lack phagocytic capacity and transfection agent is required for sufficient internalization of SPIO for cellular imaging.
If the initial amount of receptors is greater than the capacity of CDE, CIE-internalization sets in abruptly, albeit to a moderate degree compared to CDE-internalization, for EGF-stimulations greater than CDE0.
Finally, if the amount of receptors is higher than the combined capacity of both pathways, CIE-internalization will be switched on equally strong as CDE-internalization for EGF-stimulations that are higher than this combined capacity (cf. Figure 2C).
The RICH2-mediated linkage to actin may also be required for the internalization of tethered virions for endosomal degradation.
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