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Not only Sn, but also other siglecs, such as Siglec-2 (CD22) and Siglec-3 (CD33) were shown to internalize specific monoclonal antibodies, with CD22 internalization being characterized as clathrin-mediated [39], [43], [44], [49], [50].
Clathrin-mediated endocytosis seemed therefore to be only partially involved in the uptake of TAT-SA, the major internalization being mediated by another, more efficient pathway.
Indeed, 5-HT3 receptor agonists and antagonists have been suggested to modulate cell surface receptor levels (Ilegems et al., 2004; Freeman et al., 2006; Rojas et al., 2010b), with receptor internalization being reported in the enteric nervous system following excess 5-HT (Freeman et al., 2006) and in recombinant systems, following exposure to palonosetron (Rojas et al., 2010b).
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Cell internalization was studied by flow cytometry and confocal microscopy.
Figure 5: C. albicans internalization is followed by fungal outgrowth.
This fundamental process of internalization is called gastrulation.
The detrimental biological consequence accompanied by cell internalization was limited.
Internalization was related to children's externalizing behavior problems.
However, masculine norms and internalization were independent predictors of DT.
In vitro internalization was determined using glioblastoma C6 cells.
A hypothetical model showing FRα internalization is presented in Fig. 4b.
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