Sentence examples for internalization and release from inspiring English sources

Meanwhile, both formulations displayed low internalization and release at pH greater than 7.

The unloading rate of the folate conjugate from the tumor into plasma is relatively slow compared to the internalization and release processes.

In particular, it has been reported that the therapeutic efficacy of drug-loaded nanoparticle greatly depends on the internalization and release of small molecules in the cancer tissues.

The combined effect of high nanoparticle internalization and controlled release of PTX from LbL-nab-PTX increased its cytotoxicity in MCF-7 and MDA-MB-231 breast cancer cells.

The design of ideal nanoparticle delivery systems should be capable of meeting the requirements of several stages of drug delivery, including prolonged circulation, enhanced accumulation and penetration in the tumor, facilitated cellular internalization and rapid release of the active drug in the tumor cells.

With the goal of rational design of systemic gene delivery system and efficient transfection of capillary endothelial cells forming the blood brain barrier (BBB), we synthesized several short polyamines with reducible disulfide backbones for pDNA packaging, internalization and consequent release from endosomal compartments.

The higher cytotoxicity potential of CChSLN might be due to that enhanced cellular internalization and controlled release of encapsulated component in comparison with CSLN.

Similar to the TAT PTD, these cationic PrP domains are sufficient to direct the uptake, internalization and cytoplasmic release of a PrP-CRE recombinase fusion protein, providing a molecular basis for PrPSc infection.

Binding of GO is followed by internalization and toxin release intracellularly leading to DNA damage and cell death [ 19].

It is therefore necessary to chemically modify PNA by fusion with cell penetrating peptides or formulation into delivery systems that can mediate cellular internalization and cytoplasmic release.

shRNA-mediated knockdown of TRAIL expression interfered with cell internalization and LDH release, while the expression of cornification markers was not significantly affected.