Sentence examples for internalization activity from inspiring English sources

Therefore, we examined the relationship between ubiquitination activity and internalization activity by using several c-MIR mutants.

This showed that neither the introduction of the alkyne moiety nor of the Cy5-label between the peptide and PMO separated by an aminohexanoic acid spacer has any impact on the internalization activity of the peptide and the exon-skipping efficacy of the PMO.

Further analysis of natural protein-derived CPPs revealed that 5 CPPs exerted in vitro tumor suppression as well as cell internalization activities (Table 2).

Ubiquitination is an important type of post-translational modification that primarily regulates endogenous protein stability, receptor internalization, enzyme activity, and protein-protein interactions.

We hypothesize that CDR internalization affects activity-dependent modifications of synaptic integrity, stability, and function of target proteins, which modulates the synaptic Ca2+ transient by mediating over-activation of calpain-2 [ 5, 17].

Here, internalization of activated receptors is required to control GSK3 activity and β-catenin stability [ 36, 37].

Live cell imaging in CHO/GHS-R1a cells demonstrated cell surface receptor labeling and internalization, and agonist activity of fluorescein-ghrelin(1 18) was confirmed by increased phosphorylation of ERK1/2.

The peptide-membrane contact is the first step of the sequential processes leading to peptide internalization and cell activity.

Thus, several 7TM receptor splice variants have been shown to differ by their pharmacological profiles, constitutive activity, internalization pattern or tissue distribution (Kilpatrick et al., 1999).

We have used these to examine how these modules affect the internalization and cytotoxic activity when tested against CLDN-expressing ovarian cancerous cells.

We therefore hypothesize that CDR internalization enhances PKC activity, which: first, reduces L7/Pcp-2 expresecond second, increases Cav2.1 expression; third, increases intracellular Ca2+, which activates Ca2+-dependent proteases such as calpain-1 and calpain-2 and thereby induces neuronal death.