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It is the sole mechanism by which sugar phosphates are internalised into the staphylococcal cell.
In this way, once the particles were internalised into the cancer cells, it was possible to obtain and analyse a tumour image in vivo.
Atg36 delivers peroxisomes to the preautophagosomal structure before being internalised into the vacuole with peroxisomes.
It is also unknown whether circulating FABP4 can be internalised into the cell to act by intracellular mechanisms.
It is therefore not astonishing that critical NGOs referred to genetic engineering as a comparator for SB [36], painting a dark picture with SB being internalised into the future agenda of big business to exploit natural resources even more aggressively.
BTX-A injected into a muscle binds irreversibly to the nerve, where it is internalised into the nerve ending, causing paralysis of the muscle by preventing the release of acetylcholine.
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Within 1 h, approximately all cells incubated with nanoparticles were fluorescent, and the amount of Nile Red internalised into these cells increased further and reached a maximum after approximately 2 h.
Taken together, the data from these experiments demonstrate that targeted vectors can be internalised into OS cells via the EPHA2 receptor and that this uptake is convincingly higher in OS cells than in hp-OBs.
While previous studies have clearly identified mechanisms through which S. aureus can become internalised into osteoblasts, thus evading the immune system and avoiding antibiotic attack, these studies failed to identify mechanisms that lead to bone destruction.
An ideal linker must be stable in blood plasma, to avoid issues of premature warhead release and off-target toxicity, but cleave to release the warhead once the ADC has been internalised into its target cells and, commonly, trafficked to the lysosome.
ToxA is internalised into plant mesophyll cells subsequent to the pathogen penetrating the leaf [ 11] and interacts with the chloroplast-localized protein ToxA-BP1 leading to collapse of photosynthesis, the accumulation of reactive oxygen species (ROS) and eventually to cell death [ 12, 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com