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Therefore, endogenous CD59 is indeed internalised in transferrin-containing vesicles, and apparent internalisation in vesicles lacking transferrin may, at least under the conditions we have employed in this study, be an artifact due to incomplete removal of surface bound antibody.
There was no reduction of the contrast efficiency after internalisation in HUVECs, which was imparted to the ability of carbon nanotubes to translocate the cell membrane.
Use of the pathogenic Aβ42 species as a model antigen in simulated vaccine formulations suggested differing mechanisms of cellular internalisation, in which fibrillar amyloid evaded lysosomal capture, even when co-deposited on particulate adjuvant materials.
Furthermore, these systems implement the expertise in the development of nanomedicines to the purpose of achieving preferential biodistribution and uptake in cancer tissues, internalisation in cancer cells, and release of the transported drugs at intracellular sites.
Just as relying on only one seed strain leaves agriculture at risk of catastrophic crop failure when new diseases emerge, the global internalisation in recent years of the monistic world view implied by the Washington consensus and neoclassical economics has left world economies exposed to simultaneous infection by the destabilising and unforeseen effects of financial innovation.
However, in order to compare tracer internalisation in AD-treated versus non-treated animals accurately, tracer metabolism should remain as far as possible unaffected by AD.
Similar(28)
The effect of albumin fragments (FRALB-C) and selected albumin-derived peptides on the internalisation of In-albumin, In-minigastrin, In-exendin and In-octreotide by megalin-expressing cells was assessed.
We hypothesised that unlike rhTRAIL, agonistic DR4/5 antibodies do not trigger receptor internalisation resulting in JNK activation in a different cellular compartment.
No mitosis was detectable for a period equivalent to a cell cycle after the BLM internalisation, resulting in the accumulation of the cells in G2.
Activation of RTK kinase activity results in internalisation of activated receptor complexes resulting in both signal propagation and degradation.
In vitro studies have shown that epratuzumab induces CD22 phosphorylation and internalisation, which in turn leads to modulation of B-cell activity.
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