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The waiting list control group allows for controlling internal validation issues such as aging.
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With BR_E_Model to endpoint D, the internal validation result is 0.142, and validation result for validation dataset is 0.349.
Useful practical recommendations became available from the early papers dealing with HER2 testing as to the use of commercially available and validated antibodies, internal validation, fixation issues, reporting and proper training of pathologists participating in HER2 testing [ 1, 23, 24, 27, 28].
The availability of internal validation in our study allows us to examine the issue of differential measurement error in more detail.
The absence of an independent validation cohort represents another weakness of this study, although internal validation using rt-PCR was performed to address this issue.
This random split enabled internal validation of the developed model in the same study and addressed the potential issue of over-optimism (over-fitting) of the model in the training set.
The number of clusters was established by internal validation indices.
All models were subjected to internal validation.
An internal validation confirmed SIENA's realism.
Internal validation was done using 10-fold cross validation (to avoid overfitting59) on 25% of the dataset and external validation evaluated the performance of the model on the left out 75% of the data.
The target groupfor the internal validation consisted of 4 experts.
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