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In targeted analysis, SIL reference standards can be used for internal standardization of peak intensities in trace analysis by use of LC HRMS or LC–(HR MS MS [ 27, 28], making this the most common use of SIL.
Bismuth was added for the internal standardization of Pb.
Gold was added to reduce intrinsic mercury memory effects, and bismuth for internal standardization of mercury (Barany et al. 1997; Date and Gray 1989; Nixon et al. 1999).
Results were consistent with defining rapid growth using internal standardization of the sample or the U.S. Centers for Disease Control and Prevention referent (Kuczmarski et al. 2002) (data not shown).
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Such in vivo labeling of microbes has been successfully used to accomplish internal standardization for quantification, to circumvent problems of signal suppression in ESI MS [ 21].
This serves as a normalization control for two-color microarrays and an internal standardization for the arrays.
National standardization of O.B.D. by the federal Environmental Protection Agency followed in 1993.
Without internal standardization, ageing of the SPME fiber is challenging, as is the variation of the MS performance.
Internal standardization (standard addition with spiked samples) was employed.
For internal standardization 100 μl of 5 mM sinigrin (Sigma-Aldrich Co., MO, USA) were added to one of the duplicates before extraction.
In addition, stable-isotopic labeling can be used for more accurate quantification (via internal standardization) and identification of compounds in different organisms.
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