We find here that the unique properties of ERAP1 extend to strong internal sequence specificity requirements for peptide substrate trimming.
In any case, the strong internal sequence specificity effects observed in our study, in combination with the structural features of the enzyme's peptide-binding site (i.e. negative electrostatic potential, Figure 7), suggest that the ERAP1 trimming preferences are not restricted to the limited sequence templates tested here, but might be more general.
Thus, diagnostic schemes may provide internal encoding specificity that enhances the formation of, and retention of, expert-type knowledge structure [ 17].
Theories and models that differ in their contextual independence, complexity of internal structures and specificity of causal processes contribute in different ways and under different conditions to the resolution of policy issues.
The latter internal control ensured specificity of EdU detection to germ cells exposed to EdU.
As an internal control, the specificity of the reaction was assessed by inhibiting PP2A activity with 1 nM OA before titration.
To probe spectrum bias in the specificities obtained in our 35 internal controls, we calculated specificities as well in the 90 IgA and IgG concentrations obtained in weeks 9 and 13 of the epidemic of all 47 subjects with no cough (Table 1).
Potter wondered if Trump's lack of specificity reflected internal divisions.
Chlamydia inclusions in untransfected cells on the same coverslip served as internal controls for the specificity of the antibody against the myc-tag.
We tested the scale's sensitivity, specificity, and internal consistency.
For the detection of involvement of the internal os, the sensitivity, specificity, PPV and NPV was 90%, 92%, 75%and97%7%, respectively.
