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The main reason for this significant difference is hence likely the more accurate approximation of the context-dependent Markov substitution process by allowing the ancestral sequences to change in between the internal speciation nodes (which is also responsible for the small differences in model estimates).
Given that this approach does not lead to significantly different parameter estimates, the increased log Bayes factor can be attributed to the more accurate approximation of the context-dependent Markov substitution process by allowing the ancestral sequences to change in between the internal speciation nodes [ 17].
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Most phylogenetic trees represent the evolutionary history of groups of organisms, with the leaves representing species (or higher taxa) and internal nodes representing speciation events.
PAINT portrays duplications as square internal nodes and speciation events as circles, and estimates of evolutionary distances as different branch lengths.
A species-tree is a rooted binary tree that represents evolutionary history of species where leaves represent extant species and internal vertices represent speciation events.
Each internal node represents a speciation: 1 species splits into several new species.
At a speciation event (internal node on the species tree; Figure 1) travelling past to present, the population splits into two isolated populations.
This can either be due to intrinsic properties of the data, (i.e., short internal branches due to speciation events closely spaced in time) or to inadequate inference methods [ 10].
The evolutionary tree is typically inferred from genetic data and is annotated by branch lengths that indicate the genetic similarity between two species, with the leaves of the tree representing the species and internal nodes representing (unobserved) speciation events.
The evolutionary relationship for a set of species is conveniently described by a tree in which the leaves correspond to the species, and the internal nodes correspond to speciation events.
We tested 13 branches as the foreground branch (i.e. the branch for which positive selection is allowed), eight branches leading to a species (pig, dog, rabbit, macaque, human, gorilla, marmoset and elephant) and five internal branches situated after speciation and before duplication events (in cow, horse, guinea pig, rat and mouse).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com