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Exact(17)
In addition, large-scale losses of internal residues from different positions of a-type ions have been observed when pure helium was used as collision gas.
We also used Molecular dynamics (MD) simulations alongside free energy and dynamics of the internal residues of the apo and holo systems to understand the binding mechanism.
All interfaces differed significantly from the background of all residues in SWISS-PROT, from the group of surface residues, and from internal residues that were not involved in non-trivial interactions.
Finally, glucose oxidase (GOx) and lactate oxidase (LOx) decorated gold nanoparticles@C60-Polyamidoamine (Au@C60-PAMAM) was bound onto Con A via a biospecific interaction between Con A and the internal residues of GOx, thus achieving a sandwich structure.
The top 2500 ligands were evaluated for their novelty and interaction with various internal residues.
To our knowledge no other aminopeptidase has been described to have such strong preferences for internal residues so distal to the N-terminus.
Similar(43)
With the knowledge of the unique fragmentations leading to internal residue losses, the misidentification of fragments and sequences of peptides may be avoided.
Except of R144, R192 and R261, which were either conserved or highly related to the catalytic activity, the top external residue K280 and the most internal residue K371 were selected.
Like a good drama should, this production leaves you with an internal residue, something to observe and ponder the next few days.
The concept of covariation has first been used to study internal residue contacts in proteins [ 18, 19].
This is because it is quite rare to return the precise motif being sought and many TP matches incorporate an additional flanking or internal residue that is over-represented but not part of the formal motif definition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com