There is a complete perturbation of the structural content (reduced interstitial collagen, increased elastic fibers) associated with damaged fibers leading to a severe disorganization of the connective tissue structure., Aging of the individuals appears to be linked to internal factors as genetic predispositions (as shown for longevity - ), hormonal status and to environmental factors.
So migraine may be considered as a disorder of psychobiological adaptation in which genetic predisposition interplays with internal and/or external environmental influences such as psycho-emotional, climatic, hormonal, dietary or other factors.
Migraine may be considered as a disorder of psychobiological adaptation in which genetic predisposition interplays with internal and/or external environmental influences such as psycho-emotional, climatic, hormonal, dietary or other factors [11].
There are internal stressors as well: a predisposition to anxiety, a sensitive temperament, and sensory processing abilities to name just a few factors.
Reliable diagnostic, therapy, and prevention strategies therefore need to integrate multiple factors that influence disease, whether of internal origin (for example, genetic predisposition, presence of biomarkers, or spatiotemporal dynamics) or external origin (for example, lifestyle, age, or fitness).
In the last decades of the 20th century, geneticists isolated internal agents genetic variations that cause inherited predisposition to specific tumour types.
Haematological imbalances and genetic predispositions were some of the internal factors reported by the cancer patients.
For example, there are internal factors like the individual's genetic predisposition to disease and general metabolic rate as well as external (environmental) factors like pollution, exposure to radiation and chemicals, drug and alcohol abuse, exercise, stress, etc.
For biological determinists we are unfree because our lives are strongly constrained by a relatively small number of internal causes, the genes for specific behaviors or for predisposition to these behaviors.
But there are also internal factors, like pre-existing illnesses (physical or mental), a general predisposition to reacting badly to stressors for whatever reason (e.g. harsh life events, genetic factors), even something like having a big ego can make things worse (if your self-image is very important to you, then finding you can't deal with something will potentially stress you even more).
