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Importantly, the experimental design provides internal, paired control fibrils for each experiment (fibrils not strained between the pipettes), which removes complications resulting from variability in the preparation.
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Gamma decay also includes two other electromagnetic processes, internal conversion and internal pair production.
In internal pair production, excess energy is directly converted within the electromagnetic field of a nucleus into an electron and a positron (positively charged electron) that are emitted together.
Internal pair production requires that the excess energy of the unstable nucleus be at least equivalent to the combined masses of an electron and a positron (that is, in excess of 1,020,000 electron volts).
As mentioned before, the branching ratio of internal pair creation for 90Zr is remarkably small compared to usual PET tracers.
A thorough explanation of the emission of β+ particles via internal pair production in the 0+ 0+ transition of 90Zr is provided elsewhere [14].
This internal pair production has been largely studied in the past because it is generated by a rare electric monopole transition (E0) between the states 0+/0+ of 90Zr.
It is worth noting that the ability of a PET scanner to perform accurate 90Y quantification relies on the knowledge of the internal pair production branching ratio.
Most recent literature findings report an internal pair production branch ratio as large as (3.186 ± 0.047) × 10−5 measured by Selwyn [58] and colleagues using a HPGe detector.
Yttrium-90 (90Y) positron emission tomography with integrated computed tomography (PET/CT) represents a technological leap from 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) by coincidence imaging of low abundance internal pair production.
It has been demonstrated that conventional PET imaging of the annihilation radiation generated by 90Y internal pair production can produce diagnostic images which can be further analyzed quantitatively [2].
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