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We failed to identify parameters associated with preclinical internal involvement in patients with early SSc or UCTD.
This disease is responsible for high economic losses due to condemnation and trim of infected carcasses, decreased leather and wool yield, loss of sales of breeding stock and deaths from internal involvement.
We should never practise formally (without internal involvement).
Similar(57)
Auto-antibody expression is a predictor of internal organ involvement, particularly lung involvement.
Clinical details pertaining to major internal organ involvement for lung fibrosis, pulmonary arterial hypertension, renal crisis and significant gastrointestinal (GI) involvement were evaluated using consensus definitions as outlined in previously published studies [ 14].
Internal IT involvement.
LS is differentiated from the systemic form of the disease, sclerosis, the Raynaud phenomenon (i.e., internal organ involvement).
The aim of the present study was to compare NVC alterations with clinical subsets, internal organ involvement, and serum VEGF levels in a cohort of selected SSc cases.
When confirmed in larger cohorts, these data may suggest a helpful role of this simple counting score as marker of internal organ involvement.
Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe skin and multiple internal organ fibrosis.
As a first step toward future treatment of internal organ involvement, an oral administration study was performed in which halofuginone was well tolerated and plasma levels surpassed the predicted therapeutic exposure.
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