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Finally, government policy should favor internal entry, both domestic and international, over acquisition.
Therefore, we tested whether this 5′UTR uses an alternative mechanism for translation initiation in vivo, internal entry or ribosomal shunting.
Positioning of the AUG codon at the end of stem-loop may provide a more productive recognition context during cap-independent initiation of translation, when the ribosome binds directly to internal entry site without unwinding and scanning upstream regions of mRNA molecule.
Our data clearly imply that internal entry of the ribosome to the AUG2 is responsible for the generation of the short isoforms of proteins 4.1R.
An internal entry indicates whether a logical 1 or 0 would result at the next state of a gene from a selected Boolean function.
Other examples have also been found in the studies of long-range interactions (Li et al. 2010), internal entry site structures (Lukavsky 2009), and steroid receptor RNA activators (Novikova et al. 2012).
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The internal entries in the table indicate whether a function will result in a logical 1 or 0 at the next state of each gene.
No major differences in the distance covered and in the number of internal entries in the open field were found among genotypes and age (Fig. 1A and B).
Substrates suitable for haloboration with 6 included dialkyl- (Table 2, entries 2 and 3), alkyl/aryl- (entries 4 6), and diaryl-substituted internal alkynes (entry 7).
New insights into the molecular mechanism of internal ribosome entry have been provided by the structural and functional analyses of both the internal ribosome entry sites and the protein factors that stimulate translation mediated by these elements.
Then there's an internal ribosome entry site.
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