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In contrast to most published experimental studies of PBDE toxicity, we used an intravenous route of exposure for dams to assure the accuracy of internal dosing.
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Internal Dose Assessed by Computer.
Organ Level Internal Dose Assessment.
IDM – Internal Dose Metrics (BLL, Pb in tissues, etc).; iv – intravenous; TM – Test Material.
The internal dose metrics [IDM] measured during in vivo experiments can also vary.
In general these neurobehavioral effects correlate well with peak internal dose metrics.
Internal dose of Penta-BDE technical mix congeners generally correlated strongly with dust.
These radionuclides, when inhaled or ingested, cause internal dose to the individual.
For that purpose, whole-body 11C-Raclopride PET data have been acquired and the corresponding internal doses estimated.
Organ residence times were used in input to the OLINDA/EXM (Organ Level INternal Dose Assessment/EXponential Modeling) code [30].
Biological reference and threshold values may be used to evaluate the internal dose and estimate its health impact(s).
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