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In paralogous pairs that have the same number of internal disordered segments but diverged in the total internal disorder length (i.e., the sum of all internal disordered segments), the half-life of the protein with the longer total internal disorder also tends to be shorter (median half-life difference is 5 min; Table S6A).
Therefore, to investigate whether the presence of internal disorder influences protein half-life, we identified proteasome-susceptible internal disordered segments as continuous stretches of at least 40 disordered amino acids (see Discussion).
Again, the converse is also true as the probability of observing a paralogous pair that has diverged in both terminal and internal disorder, and in which the paralog with the longest terminal disordered segment and most internal disordered segments has the longer half-life, is very small (p[divergence of N-terminal and internal disorder given longer half-life] = 0.01; Table 2C).
To quantify the contribution of internal disorder to protein half-life, we computed conditional probabilities for finding proteins with and without internal disordered segments within specific half-life ranges.
Consistent with this observation, we find that the probability of having both terminal and internal disordered segments among proteins with a long half-life is very low (p[long N-terminal and internal disorder given long half-life] = 0.04; Table 1C).
The social disorder of Verona is matched by the internal disorder of the lovers-to-be.
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Most of these victims have internal disorders, such as kidney malfunctions.
Like the hair, the nails may be useful indicators of skin diseases and of internal disorders.
Internal disorders and changing trade routes caused the kingdom to suffer political and economic decline, and in 525, after several unsuccessful attempts, Abyssinian invaders finally crushed the Ḥimyarites.
Laugier-Hunziker-Baran syndrome represents a rare acquired pigmentary disorder which has no relevance to internal disorders and has no familial association.
He wished to make private property sacred because upon it he planned to build a strong central government, one capable of suppressing internal disorders and assuring tranquillity.
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