Δloop and ΔCt indicate internal deletions of uL23, lacking residues 65 69 and 83 94, respectively.
In agreement, full-length segments compete with corresponding defective interference particles (segments that have internal deletions)8,9,10.
A major threat to genome integrity is broken DNA that can be misrepaired to cause gross chromosomal rearrangements (GCR) such as translocations, internal deletions or terminal truncations.
In contrast, we found that a "micro-utrophin," with more extensive internal deletions, is as effective as full-length dystrophin in the regulation of actin dynamics.
Analysis of additional 3' internal deletions mutants revealed that progeny with a repaired sequence reminiscent of wt secondary structure were competent for replication and systemic spread.
Also, analysis involving internal deletions of the hairpin loops of the ribosomal proteins uL4 and uL22, which contribute to the formation of the tunnel constriction, suggested that they are also important for the elongation arrest25.
Four other tumors were noted to have internal deletions of the EGFR gene.
Partial internal deletions of the P element result in different RpII215 activity levels, which appear to depend on the specific sequences that remain after excision.
These variants, "protein 4.1 68/65)" and "protein 4.1 95)," have altered molecular weights due to internal deletions and duplications apparently localized around the spectrin-actin binding domain.
Internal deletions were generated using the inverse PCR method.
Second, Rag-mediated internal deletions in the Bcl11b gene locus were detected in premalignant DKO thymocytes.
