It's different, but if it's interesting, who cares? "Dancing to Miles" and "Internal Constellation" look, from a distance, like exercises in nuanced color and tone.
Two lineages with stable internal protein constellations have circulated among humans without reassorting.
Their internal protein constellations appear so interdependent that the two lineages never reassort with each other or with zoonotic viruses.
H5N1 isolates of 1981 , 1997and 2004 clearly present distinct internal protein constellations, and grouping them into a homogeneous set reveals little about their ability to adapt to humans.
A remarkable product of this complex adaptive system is the stability of internal protein constellations in the two lineages that circulate amongst humans.
Even so, our data clearly indicates that internal protein constellations form stable lineages in humans, and natural reassortments of internal proteins do not tend to occur between these lineages.
In spite of their common origin (Figure 1), the internal protein constellations of these two lineages have evolved independently, following the disappearance of H1N1 in 1957 and its reintroduction in 1977 [19].
Therefore, Pakistani-origin H9N2 viruses with various combinations of H7N3 internal gene constellations are likely being continually introduced into Bangladesh poultry via India.
Several lines of evidence indicate that the H5N1 viruses have evolved to more virulent forms since 1997, with different antigenic structure (21 ), internal gene constellations (22 ), and an expanded host range (23, 24 ).
The endemicity of HPAI A(H5N1) in poultry and wild birds also led to the generation of novel reassortant H5 strains that inherited neuraminidases (NAs) and internal gene constellations from other prevailing subtypes of avian viruses circulating in the field.
