The desirable state is "constancy," internal peace and absence of conflict.
The premise of the standard regulatory model, "homeostasis", is flawed: the goal of regulation is not to preserve constancy of the internal milieu.
Therefore, the BBB plays a crucial role in the regulation of the constancy of the internal environment of the brain and is essential for the supply of the CNS with nutrients.
Thus, with regard to reliability, the Portuguese version of SEPS has good internal consistency and very good temporal constancy.
The process thus promotes homeostasis, the constancy of the organism's internal environment.
To assess the reliability of the Portuguese version of SEPS we verified its temporal constancy measured by test-retest and internal consistency using Chronbach's alpha.
Furthermore, before using any rate for dating historical events, whether calculated from an internal calibration or borrowed from the literature, nrITS rate constancy should be tested within the group of interest, ideally with a tree-based likelihood ratio test [ 33, 34], and any lack of local rate constancy should be considered in the dating methodology [ 35].
Its scientific origin is rooted in the studies of French physiologist Claude Bernard (1813 78), who made the key observation that complex organisms such as humans go to great lengths to preserve the constancy of what he called the "milieu intérieur" (internal environment).
A major concern regarding the choice of internal reference gene control in viral gene expression studies is the constancy of the reference gene products throughout the entire examination period.
In addition to constancy of expression level, the expression level of an internal control compared to that of the genes being analyzed might be important to consider in certain cases.
