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In this structure, four extensive intermolecular interfaces are observed, suggesting potential models for APOBEC3G oligomerization.
The inter-hexamer and intra-hexamer contacts have been defined; as mentioned above, although both immature Gag and mature CA assemble into hexameric lattices, the intermolecular interfaces in the two structures differ considerably43 (Fig. 5a,b).
Assembly of the mature human immunodeficiency virus type 1 (HIV-1) capsid involves the oligomerization of the capsid protein, CA. During retroviral maturation, the CA protein undergoes structural changes and forms exclusive intermolecular interfaces in the mature capsid shell, different from those in the immature precursor.
Another simple explanation suggests that disordered proteins form very large intermolecular interfaces within complexes.
Since experimental (dis)assembly pathways appear to be driven primarily by interface size, we wondered whether fusion may preferentially occur in obligate complexes that form large intermolecular interfaces.
From the high resolution C1 map, each MAVS CARD monomer interacts with six nearby monomers using three types of intermolecular interfaces (I, II and III).
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The effects of 3CD proteins and mutations at polymerase-polymerase intermolecular Interface I were most consistent with allosteric effects on the catalytic 3D polymerase molecule.
However, unique conformational adaptations in the receptor domain geometry and intermolecular interface explain the cross-reactivity of CSF-1R for two such distantly related ligands.
The main crystalline peak at 19.50° with the d-spacing of 4.55 A° is assigned to the strong intermolecular interface linking of the PVA chains via intermolecular hydrogen bonding.
In addition, disordered proteins provide a larger intermolecular interface with a smaller protein size [30].
L95 is located near the intermolecular interface with Cul3 (Fig. 4A).
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