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However, unique conformational adaptations in the receptor domain geometry and intermolecular interface explain the cross-reactivity of CSF-1R for two such distantly related ligands.
The main crystalline peak at 19.50° with the d-spacing of 4.55 A° is assigned to the strong intermolecular interface linking of the PVA chains via intermolecular hydrogen bonding.
In addition, disordered proteins provide a larger intermolecular interface with a smaller protein size [30].
L95 is located near the intermolecular interface with Cul3 (Fig. 4A).
Residue F100a participates in the structural paratope, and therefore this residue is likely critical for the intermolecular interface.
Using U2B″ as a model, we calculated that 40% of the SNF RRM1 surface is part of an intermolecular interface.
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In this structure, four extensive intermolecular interfaces are observed, suggesting potential models for APOBEC3G oligomerization.
Assembly of the mature human immunodeficiency virus type 1 (HIV-1) capsid involves the oligomerization of the capsid protein, CA. During retroviral maturation, the CA protein undergoes structural changes and forms exclusive intermolecular interfaces in the mature capsid shell, different from those in the immature precursor.
Another simple explanation suggests that disordered proteins form very large intermolecular interfaces within complexes.
Since experimental (dis)assembly pathways appear to be driven primarily by interface size, we wondered whether fusion may preferentially occur in obligate complexes that form large intermolecular interfaces.
Such molecular interactions that define the host-microbe interface are generally non-covalent in nature and frequently involve extensive intermolecular interfaces and multivalent binding.
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